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产品中心 药物靶点和Fc受体 药物靶点

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MOG His Tag Protein, Human

BTN6,BTNL11,MOGIG2,NRCLP7,Myelin oligodendrocyte glycoprotein

价格 ￥1,500.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010998
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    BTN6, BTNL11, MOGIG2, NRCLP7, Myelin oligodendrocyte glycoprotein

  • Accession

    Q16653-1

  • 表达序列

    Gly30-Gly154, with N-terminal His

  • 表达宿主

    E.coli

  • 分子量

    19kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Reindl, M. et al. (2013) Nat. Rev. Neurol. 9:455.

背景介绍

  • Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily. Mouse MOG is synthesized with a 28 amino acid (aa) signal sequence, a 128 aa extracellular domain (ECD) containing an Ig-like domain, a 21 aa transmembrane domain, and a 69 aa cytosolic fragment featuring a hydrophobic domain that associates with the cytoplasmic face of the plasma membrane. MOG is expressed exclusively by oligodendrocytes in the central nervous system (CNS) and is localized to the outer layer of the myelin sheath as well as in the oligodendrocyte plasma membrane. This makes MOG a potential target of cellular and humoral immune responses in inflammatory demyelinating diseases.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized MOG His Tag Protein, Human (Cat. No. UA010998) at 2.0μg/mL (100μL/well) can bind Myelin Oligodendrocyte Glycoprotein (MOG) Recombinant Rabbit mAb (S-1384-61) (Cat. No. S0B0812) with EC50 of 0.72-0.90ng/mL.

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