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产品中心 蛋白 药物靶点和Fc受体

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PCSK9 His Tag Protein, Human

Proprotein Convertase Subtilisin/Kexin Type 9,Neural Apoptosis-Regulated Convertase 1,NARC-1,Proprotein Convertase 9,PC9,Subtilisin/Kexin-Like Protease PC9,PCSK9,NARC1

价格 ￥950.00 （ 1-2周）
货号 UA010997
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1

  • Accession

    Q8NBP7

  • 表达序列

    Gln31-Gln692, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    Theoretical:72.7kDa Actual:65kDa

  • 纯度

    ＞95% by SDS-PAGE&>95% by SEC-HPLC

  • 内毒素含量

    <1EU/μg

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
    • 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.


背景介绍

  • Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.

  • 电泳

    • 2μg (R: reducing conditions)

  • ELISA

    • Immobilized PCSK9 His Tag Protein, Human at 1 μg/mL (50 μL/well) can bind Proprotein convertase 9/PCSK9 Recombinant Rabbit mAb (SDT-424-113) (Cat. No. S0B0234) with EC50 of 2.938-3.598 ng/ ml.

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