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物种
Human分子别名
High Mobility Group Protein B2; High Mobility Group Protein 2; HMG-2; HMGB2; HMG2Accession
P26583表达序列
Gly2-Glu209, at the C-terminus with a 6*His tag
表达宿主
HEK293分子量
25.07 KDa
纯度
>95% by SDS-PAGE
内毒素含量
<1EU/μg标签
His Tag性状
Lyophilized Powder缓冲体系
20mM Tris-HCl, 100mM NaCl, pH 8.0.
溶解方法
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cells. HMGB2 contains 2 HMG box DNA-binding domains. It is associated with chromatin and has the ability to bend DNA, preferentially single-stranded DNA. It is shown that HMGB2 is able to efficiently bend DNA and form DNA circles. In addition, HMGB2 is involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.
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