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物种
Human分子别名
High Mobility Group Protein B1; High Mobility Group Protein 1; HMG-1; HMGB1; HMG1Accession
P09429表达序列
Met1-Phe89表达宿主
E.coli分子量
10.4 KDa
纯度
>95% by SDS-PAGE
内毒素含量
<1EU/μg标签
No Tag性状
Lyophilized Powder缓冲体系
50mM HEPES, 500mM NaCl, 0.5mMDTT, pH 7.9 .溶解方法
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses.
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