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产品中心 药物靶点和Fc受体 药物靶点

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NCAM-1/CD56 His Tag Protein, Rat

N-CAM-1,NCAM-1,CD56,MSK39,NCAM1

价格 ￥1,600.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010958
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Rat

  • 分子别名

    N-CAM-1, NCAM-1, CD56, MSK39, NCAM1

  • Accession

    P13596-1

  • 表达序列

    Leu20-Thr721, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    95-115kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & >95% by SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, 5% trehalose, PH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Reyes AA. et al., 1991, Mol Cell Biol. 11 (3): 1654-61.
    2.Suzuki M. et al., 2003, J Biol Chem. 278 (49): 49459-68.
    3.Becker C G. et al., 1996, J Neurosci Res. 45 (2): 143-52.

背景介绍

  • NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobulin superfamily. Human NCAM-1 is synthesized as a 761 aa preproprecursor, containing a signal sequence, a large GPI-linked extracellular domain (ECD), and a short C-terminal prosegment. The mature ECD contains five C-2 type Ig-like domains and two fibronectin type III domains. The mature human ECD shares 93% and 95% aa sequence identity with the mouse and rat NCAM-1 ECD, respectively. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. NCAM1 is involved in neuron-neuron adhesion, neurite fasciculation, the outgrowth of neurites, etc. It has also been shown to be involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Diseases associated with NCAM1 include Rabies and Bile Duct Cancer. Among its related pathways are Neuroscience and RET signaling.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of NCAM-1/CD56 His Tag, Rat is greater than 95% as determined by SEC-HPLC.

  • ELISA

    • Immobilized NCAM-1/CD56 His Tag Protein, Rat (Cat. No. UA010958) at 2.0μg/mL (100μL/well) can bind NCAM /CD56 Rabbit mAb (A23300) with EC50 of 0.48-0.81ng/mL.

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