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产品中心 药物靶点和Fc受体 药物靶点

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NGFR/TNFRSF16 Fc Chimera Protein, Human

Gp80-LNGFR,NGF Receptor,Low Affinity Neurotrophin Receptor P75NTR,Nerve Growth Factor Receptor (TNFR Superfamily,Member 16),NGFR,TNFR Superfamily,Member 16,Tumor Necrosis Factor Receptor Superfamily Member 16,CD271,CD271 Antigen,Low Affinity Nerve Growth Factor Receptor,Low-Affinity Nerve Growth Factor Receptor,P75 ICD,Nerve Growth Factor Receptor,P75(NTR),TNFRSF16,P75NTR

价格 ￥1,300.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010954
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Gp80-LNGFR，NGF Receptor，Low Affinity Neurotrophin Receptor P75NTR，Nerve Growth Factor Receptor (TNFR Superfamily， Member 16)，NGFR，TNFR Superfamily， Member 16，Tumor Necrosis Factor Receptor Superfamily Member 16，CD271，CD271 Antigen，Low Affinity Nerve Growth Factor Receptor，Low-Affinity Nerve Growth Factor Receptor，P75 ICD，Nerve Growth Factor Receptor，P75(NTR)，TNFRSF16，P75NTR

  • Accession

    P08138-1

  • 表达序列

    Lys29-Asn250, with C-hIgG Fc

  • 表达宿主

    HEK293

  • 分子量

    70-90kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & >90% by RP-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Barker, P.A. and R.A. Murphy (1992) Molecular and Cellular Biochemistry 110:1.
    2.Bamji, A.X. et al. (1998) J. Cell Biol. 140:911.
    3.Feinstein, E. et al. (1995) Trends Biochem. Sci. 20:342.

背景介绍

  • p75 neurotrophin receptor, also named low affinity NGF receptor (NGF R), is a type I transmembrane protein that belongs to the tumor necrosis factor receptor family. The extracellular region contains four cysteine-rich domains and binds NGF, BDNF, NT-3 and NT-4 approximately equally with low affinity. The cytoplasmic region contains a subtype 2 death domain. NGF R expression has been shown to occur widely during development and in the adult. Expression has been detected in both neuronal and non-neuronal cells. NGF R was originally reported to function as a positive regulator of TrkA activity. NGF R has also been shown to signal by itself. Depending on its cellular environment, NGF R has now been shown to regulate cell migration, gene expression and to mediate apoptosis. Recombinant NGF R/Fc chimera binds NGF with high affinity and is a potent NGF antagonist. Naturally occurring truncated NGF R containing the extracellular domain and lacking the transmembrane or intracellular domain has been detected in vivo in urine, plasma and in amniotic fluid of humans and rats.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

    • The purity of Biotinylated NGFR/TNFRSF16 Fc Chimera, Human is greater than 90% as determined by RP-HPLC.

  • SPR

    • Protein A Chip captured NGFR/TNFRSF16 Fc Chimera, Human (Cat. No. UA010954), can bind NT-4 Human (Cat. No. UA040069) with an affinity constant of 7.06nM as determined in SPR assay.

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