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物种
Human分子别名
FAS, ALPS1A, APO1, APT1, CD95, FAS1, FASTM, TNFRSF6, FasRAccession
P25445-1表达序列
Gln26-Asn173, with C-hIgG Fc表达宿主
HEK293分子量
50-60kDa (Reducing)
纯度
＞95% by SDS-PAGE & >95% RP-HPLC内毒素含量
<0.1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
PBS, pH7.4, 5% trehalose溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
Review Cell Death Differ . 2012 Jan;19(1):42-50.Epub 2011 Sep 30.
Fas, also known as APO-1 or CD95, belongs to the death receptor subfamily of the TNF receptor superfamily and is a prototypical death receptor characterized by the presence of an 80-amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant.
电泳
1μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
The purity of Fas/TNFRSF6/CD95 Fc Chimera, Human is greater than 95% as determined by RP-HPLC.
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