分享产品介绍 评论(0)
物种
Human分子别名
NKG2D, CD314, KLRK1, NK cell receptor DAccession
P26718-1表达序列
Phe78-Val216, with N-terminal His表达宿主
HEK293分子量
25-35kDa (Reducing)纯度
＞95% by SDS-PAGE内毒素含量
<0.1EU/μg标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, 5% trehalose, PH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1. Wang J, Wang Y, Jiang X, Xu M, Wang M, Wang R, Zheng B, Chen M, Ke Q, Long J. Unleashing the power of immune checkpoints: Post-translational modification of novel molecules and clinical applications. Cancer Lett. 2024 Feb 22:216758.
2. Wang X, Zhang Y, Xue S. Recent progress in chimeric antigen receptor therapy for acute myeloid leukemia. Ann Hematol. 2024 Feb 21.
NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular proteins incapable to transduce signals. NKG2D also plays an important role in viral control. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis.
电泳
SPR
Protein A Chip captured MICB Fc Chimera protein, Human (Cat. No. UA010583), can bind NKG2D/CD314 His Tag, Human (Cat. No. UA010938) with an affinity constant of 0.25μM as determined in SPR assay.
评论(0)