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物种
Human分子别名
NKG2D,CD314,KLRK1,NK cell receptor DAccession
P26718-1表达序列
Phe78-Val216, with N-terminal Avitag and hIgG1表达宿主
HEK293分子量
50-70kDa (Reducing)
纯度
＞95% by SDS-PAGE & RP-HPLC内毒素含量
<1EU/μg活性
Immobilized Biotinylated NKG2D/CD314 Avi&Fc Tag Protein, Human (Cat. No. UA010921) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind MICB His Tag Protein, Human (Cat. No. UA010590) with EC50 of 43.01-73.67 ng/ml.标记
Biotin标签
Human Fc Tag, Avi Tag性状
Lyophilized powder缓冲体系
PBS, pH7.4, 5% trehalose溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.Cerwenka, A. et al. (2001) Proc. Natl. Acad. Sci. USA 98:11521. 2.Diefenbach, A. et al. (2001) Nature 413:165. 3.NKG2D and its Ligands (2002) www.rndsystems.com.
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human ligands for NKG2D include MICA, MICB, and ULBP1,2, and 3. Expression of NKG2D ligands occurs in epithelial cells, tumor cells and under conditions of stress or infection. NKG2D exists as a disulfide-linked homodimer that delivers an activating signal upon ligand binding. NKG2D has been implicated in anti-tumor surveillance and the immune response against viral infection. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity.
电泳
反相高效液相色谱(RP-HPLC)
ELISA
Immobilized Biotinylated NKG2D/CD314 Avi&Fc Tag Protein, Human (Cat. No. UA010921) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind MICB His Tag Protein, Human(Cat. No. UA010590) with EC50 of 43.01-73.67 ng/ml.
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