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DUSP6 His Tag Protein, Human

Dual specificity protein phosphatase 6,Dual specificity protein phosphatase PYST1,Mitogen-activated protein kinase phosphatase 3 (MAP kinase phosphatase 3,MKP-3)

Datasheet COA

价格￥1,280.00 （供应商现货： 3-5个工作日）

货号 UA010908

规格

25μg100μg

数量

产品介绍

产品介绍评论(0)

产品规格

物种

Human
分子别名

Dual specificity protein phosphatase 6,Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3 (MAP kinase phosphatase 3,MKP-3)
Accession

Q16828
表达序列

Met1-Thr381, with N-terminal His
表达宿主

E.coli
分子量

43kDa
纯度

＞95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

His Tag
性状

Lyophilized Powder
缓冲体系

PBS, 2mM TCEP, pH7.4
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

Nat Commun. 2022 Nov 5;13(1):6672.
Int J Mol Sci. 2023 Apr 22;24(9):7690.

背景介绍

Dual-specific phosphatase-6 (DUSP6), also known as mitogen-activated protein kinase phosphatase-3 (MKP3), has been characterized as a negative feedback regulator of ERK1/2 signaling. It serves a specific and conserved function on the dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). DUSP6 is a cytoplasmic DUSP known to catalyze the removal of phosphate groups from threonine and tyrosine residues on Erk1/2, Which belongs to a family of 25 protein phosphatases that dephosphorylate phosphotyrosine and phosphoserine/phosphothreonine residues within the same substrate.