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产品中心 药物靶点和Fc受体 药物靶点

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Endoglin/CD105 Fc Chimera Protein, Human

Endoglin,CD105,ENG,END

价格 ￥1,480.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010906
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Endoglin,CD105,ENG,END

  • Accession

    P17813-1

  • 表达序列

    Glu26-Gly586, with C-hIgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    90-95kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    1*PBS, pH7.4,5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.MINI REVIEW article Front. Med., 30 January 2019 Sec. Translational Medicine Volume 6 - 2019 | https://doi.org/10.3389/fmed.2019.00010.

背景介绍

  • Endoglin (ENG), endothelial glycoprotein, also known as CD105, is a coreceptor of the transforming growth factor-β (TGFβ) family signaling complex, which is highly expressed on endothelial cells and plays a key role in angiogenesis. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. As a TGF-beta coreceptor, CD105/Endoglin activates SMAD transcription factors, participating in the TGF-beta/BMP signaling cascade.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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