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产品中心 药物靶点和Fc受体 药物靶点

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GPNMB His Tag Protein, Human

HGFIN,NMB,Osteoactivin

价格 ￥1,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010893
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    HGFIN, NMB, Osteoactivin

  • Accession

    Q14956

  • 表达序列

    Lys23-Asn498, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    80-95kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Hassan Ashktorab, Hamed Rahi. GPNMB methylation: a new marker of potentially carcinogenic colon lesions. BMC Cancer 2018 Nov 6;18(1):1068.

背景介绍

  • GlycoProtein Non-metastatic Melanoma B (GPNMB)was discovered in 1995, through a study on two melanoma cell lines with low and high metastatic abilities. The authors determined and characterized GPNMB cDNA that was highly expressed in the low metastatic cell line. GPNMB is located on the short arm of chromosome 7 (7p15) and known as neurokinin-1 type, hematopoietic growth factor inducible (HGFIN). It is a type I transmembrane protein that has three unique domains: an extracellular, a transmembrane, and a cytoplasmic one. The extracellular domain consists of two regions with different properties, an integrin-binding motif (RGD) and a polycystic kidney disease (PKD) domain. The cytoplasmic tail has two functionally different parts including a dileucine-based sorting signal and a half immunoreceptor tyrosine-based activation motif(hemITAM).

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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