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产品中心 药物靶点和Fc受体 药物靶点

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IL-18Rα/IL-1R5 Fc Chimera Protein, Human

CD218a,CDw218a,IL18R1,IL18RA,IL-18Ralpha,IL-18R-alpha,IL18Ralpha2,IL1RRP,IL-1Rrp,Interleukin-18 receptor 1,IL-1 R5,IL-1 Rrp,IL-18 R alpha,IL-18 R1,IL18R alpha,IL-18Ra

价格 ￥496.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010874
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CD218a;CD218a;CDw218a;IL18R1;IL18RA;IL-18Ralpha;IL-18R-alpha;IL18Ralpha2;IL1RRP;IL-1Rrp;Interleukin-18 receptor 1; IL-1 R5; IL-1 Rrp; IL-18 R alpha; IL-18 R1; IL18R alpha; IL18R1; IL-18Ra

  • Accession

    Q13478

  • 表达序列

    Cys22-Arg329, with C-hIgG Fc

  • 表达宿主

    HEK293

  • 分子量

    80-90kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Parnet, P. et al. (1996) J. Biol. Chem. 271:3967.

背景介绍

  • Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immuno-regulatory functions with IL-12. The functional IL-18 receptor complex is composed of two subunits designated IL-18 R alpha (also termed IL-1 R5 and IL-1 Rrp) and IL-18 R beta (also termed IL-1 R7 and AcPL). Both IL-18 R alpha and IL-18 R beta belong to the IL-1 receptor superfamily. IL-18 R is widely expressed in numerous tissues including spleen, thymus, leukocyte, liver, lung, heart, small and large intestine, prostate and placenta. Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either. independently of SLC12A3, or as a complex with SLC12A3.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Measured by its binding ability in a functional ELISA. When IL-18Rβ/IL-1R7 His Tag, Human (Cat. No. UA010888) is immobilized at 2.0µg/mL (100 µL/well), in the present of IL-18, Human (Cat. No. UA040111), IL-18Rα/IL-1R5 Fc Chimera, Human (Cat. No. UA010874) binds with an ED50 of 8.62-11.50 ng/mL.

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