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产品中心 药物靶点和Fc受体 药物靶点

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IL-18Rβ/IL-1R7 Fc Chimera Protein, Human

Accessory protein-like,AcPL,CD218 antigen-like family member B,CD218b antigen,CD218b,CDw218b,IL-1 R7,IL-18 R beta,IL-18 receptor accessory protein,IL-18 receptor beta,IL18R beta,IL-18RAcP,IL18RAP,IL18RB,IL-18Rb,IL-18Rbeta,IL-18R-beta,IL-1R accessory protein-like,IL1R7,IL-1R7,IL-1R-7,IL-1RAcPL,interleukin 18 receptor accessory protein,Interleukin-1 receptor 7,interleukin-18 receptor accessory protein,Interleukin-18 receptor accessory protein-like,Interleukin-18 receptor beta,MGC120589,MGC120590

价格 ￥800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010873
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Accessory protein-like; AcPL; CD218 antigen-like family member B; CD218b antigen; CD218b; CDw218b; IL-1 R7; IL-18 R beta; IL-18 receptor accessory protein; IL-18 receptor beta; IL18R beta; IL-18RAcP; IL18RAP; IL18RB; IL-18Rb; IL-18Rbeta; IL-18R-beta; IL-1R accessory protein-like; IL1R7; IL-1R7; IL-1R-7; IL-1RAcPL; interleukin 18 receptor accessory protein; Interleukin-1 receptor 7; interleukin-18 receptor accessory protein; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta; MGC120589; MGC120590

  • Accession

    O95256

  • 表达序列

    Phe20-Arg356 with Human IgG1 Fc at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    72-95kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE & SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    When IL-18Rβ/IL-1R7 Fc Chimera Protein, Human (Cat. No. UA010873) is immobilized at 2.0µg/mL (100 µL/well), in the present of IL-18, Human (Cat. No. UA040111), IL-18Rα/IL-1R5 His Tag Protein, Human (Cat. No. UA010914) binds with an ED50 of 40.10-49.63ng/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4,5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Parnet, P. et al. (1996) J. Biol. Chem. 271:3967.

背景介绍

  • Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immunoregulatory functions with IL-12. The functional IL-18 receptor complex consists of two subunits: IL-18Rα (also known as IL-1R5 or IL-1Rrp) and IL-18Rβ (also known as IL-1R7 or AcPL). Both subunits belong to the IL-1 receptor superfamily. IL-18R is widely expressed in various tissues, including the spleen, thymus, leukocytes, liver, lung, heart, small and large intestines, prostate, and placenta.
    The IL-18 receptor complex is responsible for binding the pro-inflammatory cytokine IL-18, but not IL-1α or IL-1β. It is involved in IL-18-mediated IFNγ synthesis from T-helper 1 (Th1) cells and contributes to IL-18-induced cytokine production, either independently of SLC12A3 or as a complex with SLC12A3.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • 96.3%

  • ELISA

    • When IL-18Rβ/IL-1R7 Fc Chimera Protein, Human (Cat. No. UA010873) is immobilized at 2.0µg/mL (100 µL/well), in the present of IL-18, Human (Cat. No. UA040111), IL-18Rα/IL-1R5 His Tag Protein, Human (Cat. No. UA010914) binds with an ED50 of 40.10-49.63ng/mL.

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