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产品中心 药物靶点和Fc受体 药物靶点

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CD300g/Nepmucin/CLM9 His Tag Protein, Human

CMRF35-Like Molecule 9,CLM-9,CD300 Antigen-Like Family Member G,Triggering Receptor Expressed on Myeloid Cells 4,TREM-4,CD300g,CD300LG,CLM9,TREM4

价格 ￥1,340.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010871
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CMRF35-Like Molecule 9; CLM-9; CD300 Antigen-Like Family Member G; Triggering Receptor Expressed on Myeloid Cells 4; TREM-4; CD300g; CD300LG; CLM9; TREM4

  • Accession

    Q6UXG3-1

  • 表达序列

    Leu19-Arg247, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    35-72kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Umemoto, E. et al. (2013) PloS One. 8:e83681. 2.Umemoto, E. et al. (2006) J. Exp. Med. 203:1603. 3.Takatsu H, et al. (2006) Biochem. Biophys. Res. Commun. 348:183.

背景介绍

  • Nepmucin, also known as CMRF35-like molecule 9 (CLM-9), TREM-4 and CD300g, is a 75-95 kDa type I transmembrane O-glycosylated member of the CD300 family of molecules. Nepmucin plays a critical role in promoting lymphocyte transendothelial migration of high endothelial veins and mediates lymphocyte adhesion with endothelial cells by its Ig domain, which is independent of LFA-1 or VLA-4 adhesion pathway. Glycosylated nepmucin with MECA-79 epitope associate with L-selectin to mediate L-selectin-dependent lymphocyte rolling by its mucin-like domain. Expression of nepmucin is down-regulated in tumours and tumour-draining lymph nodes, indicating that the expression of nepmucin is negatively regulated by locally produced signals under these circumstances. Nepmucin induction can significantly improve the killing activity of CIK cells.Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

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