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Siglec-1 His Tag Protein, Human

Sialic acid-binding Ig-like lectin 1,Siglec-1,CD169

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010865
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Sialic acid-binding Ig-like lectin 1, Siglec-1, CD169

  • Accession

    Q9BZZ2-1

  • 表达序列

    Ser20-Gln1641, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    175-190kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Crocker P.R., Paulson J.C., Varki A. Siglecs and their roles in the immune system. Nat. Rev. Immunol. 2007; 7:255–266.
    Hartnell A., Steel J., Turley H., Jones M., Jackson D.G., Crocker P.R. Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Blood. 2001; 97:288–296.
    Puryear W.B., Akiyama H., Geer S.D., Ramirez N.P., Yu X., Reinhard B.M., Gummuluru S. Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169. PLoS Pathog. 2013; 9: e1003291.
    Rempel H., Calosing C., Sun B., Pulliam L. Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity. PLoS ONE. 2008; 3: e1967.

背景介绍

  • Human Siglec-1, a 175-185 kDa glycoprotein, also known as sialoadhesin or CD169, selectively binds to 2,3-linked sialic acid residues. Siglec-1 is a type I transmembrane lectin with an amino-terminal V-set domain that interacts with sialylated ligands, preferentially N-acetylneuraminic acid (Neu5Ac) in an α2–3 linkage. Moreover, as Siglec-1 contains 16 Ig-like C2-type extracellular domains that separate the ligand-binding site from the cell surface, it is available for interaction with external ligands and not bound in cis to cell-surface molecules, which is what usually happens with shorter Siglecs that are also expressed by DCs. Siglec-1 is a receptor codified by an interferon-stimulated gene and is therefore potently upregulated on distinct human DCs, monocytes, and macrophages when these cells sense type I interferons (IFNs) such as IFNα.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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