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PSGL-1/CD162 His Tag Protein, Human

Selectin P ligand,P-selectin glycoprotein ligand 1,PSGL-1,CD162

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010863
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Selectin P ligand, P-selectin glycoprotein ligand 1, PSGL-1, CD162

  • Accession

    Q14242-1

  • 表达序列

    Gln42-Cys320, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    64-93kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Ye Z, Zhong L, Zhu S, Wang Y, Zheng J, Wang S, Zhang J, Huang R. The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway. Cell Death Dis. 2019; 10:507.

背景介绍

  • PSGL-1, a major selectin ligand on leukocytes, binds P-selectin, E-selectin, and L-selectin under flow conditions. PSGL-1 is a sialomucin of 120 kD that forms disulfide-linked (C320) homodimers. These have two subunits each contain two to three N-glycans, which are critical for P-selectin binding. Each subunit consists of an extracellular, transmembrane, and cytoplasmic domain. PSGL-1 is expressed on most peripheral T cells and on some B cells, neutrophils, monocytes, and platelets. PSGL-1 requires N-terminal tyrosine sulfation for high-affinity P-selectin binding. The PSGL-1 cytoplasmic domain binds ERM proteins, thereby linking PSGL-1 to the actin cytoskeleton. Recently, PSGL-1 has been shown to be of key importance for the delivery of tissue factor to sites of thrombosis. Blocking functional PSGL-1 reduces visceral adipose inflammation and ameliorates endothelial dysfunction in atherosclerosis.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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