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产品中心 药物靶点和Fc受体 药物靶点

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CD300e/LMIR6 Fc Chimera Protein, Human

CD300LE,CLM2,CMRF35A5,IREM2

价格 ￥3,200.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010857
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CD300LE, CLM2, CMRF35A5, IREM2

  • Accession

    Q496F6

  • 表达序列

    Leu18-Leu169, with C-terminal hIgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    55-72kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Sara Coletta,Ambra Bertocco.The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation. Sci Rep. 2020 Oct 5;10(1):16501.

背景介绍

  • CD300e, originally termed immune receptor expressed by myeloid cells (IREM)-2, is a glycosylated surface receptor with a single extracellular Ig-like domain, belonging to a family of immune receptors that includes 8 members, either activating or inhibitory, that are expressed on myeloid cells, on lymphoid cells or on both compartments1. Since the ligand of CD300e is still unknown, its function in human cells has been studied by using an agonistic anti-CD300e monoclonal antibody2. The evidence that the engagement of CD300e in human monocytes and myeloid dendritic cells provided the cells with survival signals and triggered the expression of the activation markers and the release of pro-inflammatory cytokines, led to the conclusion that CD300e is an immune-activating receptor2. The presence of a lysine residue in the transmembrane domain suggested that CD300e might associate with an ITAM-containing adaptor molecule.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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