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产品中心 药物靶点和Fc受体 药物靶点

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Biotinylated EphA2 His&Avi Tag Protein, Human

ECK,MPK-5,MPK5,SEK-2,SEK2,Myk2

价格 ￥2,780.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010833
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    ECK,MPK-5,MPK5,SEK-2,SEK2,Myk2

  • Accession

    P29317-1

  • 表达序列

    Ala24-Val537, with C-terminal His and Avitag

  • 表达宿主

    HEK293

  • 分子量

    50-55kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Ping Zhao. EphA2: A promising therapeutic target in breast cancer. J Genet Genomics. 2021 Apr 20;48(4):261-267. Epub 2021 Mar 29.

背景介绍

  • Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase, is overexpressed in human breast cancers often linked to poor patient prognosis. Accumulating evidence demonstrates that EphA2 plays important roles in several critical processes associated with malignant breast progression, such as proliferation, survival, migration, invasion, drug resistance, metastasis, and angiogenesis. As its inhibition through multiple approaches can inhibit the growth of breast cancer and restore drug sensitivity, EphA2 has become a promising therapeutic target for breast cancer treatment.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized Ephrin-A1 His Tag, Human (Cat. No. UA010170) at 2.0μg/mL (100μL/well) can bind Biotinylated EphA2 His&Avi Tag (Cat. No. UA010833) with EC50 of 0.25-0.36μg/mL .

    • Immobilized Biotinylated EphA2 His&Avi Tag Protein, Human (Cat. No. UA010833) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind Ephrin-A1 Fc Chimera Protein, Human (Cat. No. UA011030) with EC50 of 1.20-1.74 ng/ml.

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