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产品中心 药物靶点和Fc受体 药物靶点

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CDH17/LI-cadherin His Tag Protein, Human

Liver-intestine cadherin,HPT-1,CDH16,Intestinal peptide-associated transporter HPT-1,LI-cadherin,HPT-1 Cadherin,Cadherin 17,LI Cadherin (Liver-Intestine),HPT1,Human Intestinal Peptide-Associated Transporter HPT-1,LI Cadherin,Cadherin,Human Peptide Transporter 1,Cadherin-16

价格 ￥2,079.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010825
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Liver-intestine cadherin，HPT-1，CDH16，Intestinal peptide-associated transporter HPT-1，LI-cadherin，HPT-1 Cadherin，Cadherin 17， LI Cadherin (Liver-Intestine)，HPT1，Human Intestinal Peptide-Associated Transporter HPT-1，LI Cadherin，Cadherin，Cadherin 17，Human Peptide Transporter 1，Cadherin-16

  • Accession

    Q12864

  • 表达序列

    Gln23-Met787, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    95-110kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Liu LX, et al. (2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology. 50(5): 1453-63.

背景介绍

  • Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. It's also involved in intestinal peptide transport.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized CDH17/LI-cadherin His Tag, Human (Cat. No. UA010825) at 2.0μg/mL (100μL/well) can bind Cadherin 17 Recombinant Rabbit mAb (SDT-736-23) (Cat. No. S0B2291) with EC50 of 1.25-1.75ng/mL.

    • Immobilized CDH17/LI-cadherin His Tag Protein, Human (Cat. No. UA010825) at 2.0μg/mL (100μL/well) can bind Anti-CDH17(ARB102 biosimilar) mAb with EC50 of 0.35-0.52ng/mL.

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