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产品中心 药物靶点和Fc受体 药物靶点

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MARCO(405-520) His Tag Protein, Human

MARCO,SCARA2,Macrophage receptor with collagenous structure,Scavenger receptor class A member 2

价格 ￥3,080.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010816
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    MARCO, SCARA2, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2

  • Accession

    Q9UEW3

  • 表达序列

    Ser405-Val520, with N-terminal His

  • 表达宿主

    HEK293

  • 分子量

    14-17kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    50mM Tris,0.1M NaCl,0.3M Arg, pH8.0.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Sheetal, A. et al. (2008) J. Immunotoxicol. 5:151.

背景介绍

  • MARCO (macrophage receptor with collagenous structure), also known as SCARA2, is an 80 kDa type II transmembrane glycoprotein that belongs to the class A scavenger receptor family. MARCO is constitutively expressed on the surface of splenic and lymph node macrophages. Its expression is induced on Kupffer cells and alveolar macrophages by microbial infection, chemical irritants, and Th1 polarizing factors. MARCO binds LPS, lipoteichoic acid, and other determinants on Gram positive and negative bacteria. It also binds modified LDL, CpG oligonucleotides, UGRP1, silica, and TiO2. MARCO is required for the organization of the splenic marginal zone and the interaction of local macrophages and B cells.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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