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产品中心 药物靶点和Fc受体 药物靶点

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NTB-A/SLAMF6 His Tag Protein, Human

NTB-A,SLAMF6,Ly108,NK-T-B-antigen,CD352,KALI

价格 ￥960.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010815
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    NTB-A, SLAMF6, Ly108, NK-T-B-antigen, CD352, KALI

  • Accession

    Q96DU3-1

  • 表达序列

    Gln22-Met226, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    33-43kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    1*PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Rietdijk, Keszei, Castro, Terhorst, Abadía-Molina (2023) Characterization of Ly108-H1 Signaling Reveals Ly108-3 Expression and Additional Strain-Specific Differences in Lupus Prone Mice. Int J Mol Sci (IF: 5.6) 24(5).

背景介绍

  • SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly18, is a single-pass type I membrane protein that belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6-related genes is located within a 400–500 kilobase (kb) genomic segment on chromosome 1 in humans and mice. The genes that encode the SLAM family were created by serial gene duplication. SLAMF6 / Ly18 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly18 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly18 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly18 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

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