4-1BB/TNFRSF9 Fc Chimera Protein, Mouse
T-cell antigen ILA,ILA,4-1BB Ligand Receptor,CD137 Antigen,CDw137,CD137,Interleukin-Activated Receptor,Homolog Of Mouse Ly63,Tumor Necrosis Factor Receptor Superfamily,Member 9,Homolog Of Mouse 4-1BB,Receptor Protein 4-1BB,T Cell Antigen ILA
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物种
Mouse分子别名
T-cell antigen ILA; ILA; 4-1BB Ligand Receptor; CD137 Antigen; CDw137; CD137; Interleukin-Activated Receptor; Homolog Of Mouse Ly63; Tumor Necrosis Factor Receptor Superfamily; Member 9; Homolog Of Mouse 4-1BB; Receptor Protein 4-1BB; T Cell Antigen ILAAccession
P20334表达序列
Val24-Leu187, with C-terminal hIgG Fc表达宿主
HEK293分子量
53-63kDa (Reducing)
纯度
＞95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated标签
Human Fc Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4.溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90. 2. Thum E, et al. (2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. The best characterized activity of CD137 is its costimulatory activity for activated T cells.
电泳
1μg (R: reducing condition, N: non-reducing condition).
ELISA
Immobilized 4-1BB Ligand/TNFSF9 His Tag, Rat (Cat. No. UA010859) at 2.0μg/mL (100μL/well) can bind 4-1BB/TNFRSF9 Fc Chimera, Mouse(Cat. No. UA010800) with EC50 of 1.97-2.67ng/mL.
Immobilized 4-1BB Ligand TNFSF9 His tag Protein，Mouse at 2.0μg/mL (100μL/well) can bind 4-1BB/TNFRSF9 Fc Chimera Protein, Mouse(Cat. No. UA010800) with EC50 of 1.79-2.13ng/mL.
SPR
Protein A Chip captured 4-1BB/TNFRSF9 Fc Chimera, Mouse (Cat. No. UA010800), can bind 4-1BB Ligand/TNFSF9 His Tag, Rat (Cat. No. UA010859) with an affinity constant of 1.60nM as determined in SPR assay.
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