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USAG1 Fc Chimera Protein, Human

CDA019,cystine-knot containing secreted protein,DKFZp564D206,Ectodermal BMP inhibitor,Ectodin,sclerostin domain containing 1,sclerostin domain-containing protein 1,SOSTDC1,USAG1,USAG-1,USAG1uterine sensitization-associated protein-1,Uterine sensitization-associated gene 1 protein,WISE

Datasheet COA

价格￥3,200.00 （供应商现货： 3-5个工作日）

货号 UA010798

规格

100μg500μg

数量

产品介绍

产品介绍评论(0)

产品规格

物种

Human
分子别名

CDA019; cystine-knot containing secreted protein; DKFZp564D206; Ectodermal BMP inhibitor; Ectodin; sclerostin domain containing 1; sclerostin domain-containing protein 1; SOSTDC1; USAG1; USAG-1; USAG1uterine sensitization-associated protein-1; Uterine sensitization-associated gene 1 protein; WISE
Accession

Q6X4U4
表达序列

Phe24-Ser206, with C-terminal hIgG1 Fc
表达宿主

HEK293
分子量

50-70kDa (Reducing)
纯度

＞90% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

Human Fc Tag
性状

Lyophilized Powder
缓冲体系

PBS, pH7.4.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1.Laurikkala, J. et al. (2003) Dev. Biol. 264:91. 2.Yanagita, M. et al. (2004) Biochem. Biophys. Res. Commun. 316:490. 3.Lintern, K.B. et al. (2009) J. Biol. Chem. 284:23159.

背景介绍

USAG1 (uterine sensitization‑associated gene 1), also called WISE (Wnt modulator in surface ectoderm) or Ectodin, gene name SOSTDC1, is a secreted, monomeric 26 ‑ 32 kDa glycoprotein of the sclerostin family of BMP antagonists. USAG1 is proposed to coordinate BMP, Wnt, FGF and SHH signals that regulate apoptosis during tooth development. Deletion of USAG1 results in mice with supernumerary teeth, while concurrent decreased expression of LRP5 and LRP6 restores normal tooth configurations. USAG1-/- mice show decreased susceptibility to kidney injury which is reversed by administration of a neutralizing antibody to BMP7. In a mouse model of Alport syndrome, deletion of USAG1 alternates disease progression. These results support a proposed USAG1/WISE antagonism of BMP and Wnt signaling pathways in kidney and tooth development. USAG1 expression by uterine luminal epithelium is also associated with the timing and positioning of blastocyst implantation.