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产品中心 药物靶点和Fc受体 药物靶点

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4-1BB/TNFRSF9 His Tag Protein, Human

TNFRSF9,4-1BB,CD137,CDw137,ILA

价格 ￥2,100.00 （ 1-2周）
货号 UA010796
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    TNFRSF9, 4-1BB, CD137, CDw137, ILA

  • Accession

    Q07011

  • 表达序列

    Leu24-Gln186, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    25-33kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90. Thum E, et al. (2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.

背景介绍

  • CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

  • ELISA

    • Immobilized 4-1BB/TNFRSF9 His Tag Protein, Human (Cat. No. UA010796)at 2.0μg/mL (100μL/well) can bind Human 4-1BB Ligand/TNFSF9 Trimer Protein with EC50 of 1.32-2.12ng/mL.

    • Immobilized 4-1BB/TNFRSF9 His Tag Protein, Human (Cat. No. UA010796)at 2.0μg/mL (100μL/well) can bind Anti-Human CD137 Monoclonal Antibody with EC50 of 23.19-25.51ng/mL.

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