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产品中心 药物靶点和Fc受体 药物靶点

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CTLA-4/CD152 His Tag Protein, Rat

CTLA4,CD152

价格 ￥2,050.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010792
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Rat

  • 分子别名

    CTLA4, CD152

  • Accession

    Q62859

  • 表达序列

    Ile38-Asp161, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    19-26kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Zhang L, Wang Y, Wang L, Wang M, Li S, He J, Ji J, Li K, Cao L. Identifying survival of pan-cancer patients under immunotherapy using genomic mutation signature with large sample cohorts. J Mol Med (Berl). 2023 Nov 18. Gnirck AC, Philipp MS, Waterhölter A, Wunderlich M, Shaikh N, Adamiak V, Henneken L, Kautz T, Xiong T, Klaus D, Tomczyk P, Al-Bahra MM, Menche D, Walkenhorst M, Lantz O, Willing A, Friese MA, Huber TB, Krebs CF, Panzer U, Kurts C, Turner JE. Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease. Nat Commun. 2023 Nov 15;14(1):7372.

背景介绍

  • Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and it is also found in regulatory T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized CTLA-4/CD152 His Tag Protein, Rat (Cat. No. UA010792) at 2.0μg/mL (100μL/well) can bind B7-1/CD80 Fc Chimera Protein, Mouse (Cat. No. UA011080) with EC50 of 1.36-1.57ng/mL.

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