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产品中心 药物靶点和Fc受体 药物靶点

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LAG-3/CD223 His Tag Protein, Rat

Lymphocyte activation gene 3 protein,LAG3,Lymphocyte Activating 3,Lymphocyte-Activation Gene 3,CD223 Antigen,Protein FDC,CD223,LAG-3,FDC,sLAG-3

价格 ￥1,180.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010786
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Rat

  • 分子别名

    Lymphocyte activation gene 3 protein，LAG3，Lymphocyte Activating 3，Lymphocyte-Activation Gene 3，CD223 Antigen，Protein FDC，CD223，LAG-3，FDC，sLAG-3

  • Accession

    Q5BK54

  • 表达序列

    Gly24-Leu442 with His Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    43-55kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE, ＞90% by SEC-HPLC &＞90% by RP-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized LAG-3/CD223 His Tag, Rat (Cat. No. UA010786) at 2.0μg/mL (100μL/well) can bind Mouse FGL1 Protein, Fc Tag with EC50 of 0.082-0.107ug/mL

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Colin G. Graydon, Shifa Mohideen and Keith R.Fowke, LAG3’s Enigmatic Mechanism of Action. Frontiers in Immunology

背景介绍

  • LAG3, a member of the immunoglobulin superfamily and a homolog of CD4, arose from a gene duplication event. Similar to CD4, LAG3 binds to MHC class II (MHCII), but it also interacts with FGL-1, α-synuclein fibrils (α-syn), galectin-3 (Gal-3), and lymph node sinusoidal endothelial cell C-type lectin (LSECtin). As an immune checkpoint, LAG3 inhibits the activation of its host cell, promoting a more suppressive immune response. On T cells, LAG3 reduces the production of cytokines and granzymes, as well as cell proliferation, while encouraging differentiation into T regulatory cells.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of LAG-3/CD223 His Tag Protein, Rat is more than 90% determined by SEC-HPLC.

  • 反相高效液相色谱(RP-HPLC)

    • The purity of LAG-3/CD223 His Tag Protein, Rat is more than 90% determined by RP-HPLC.

  • ELISA

    • Immobilized LAG-3/CD223 His Tag, Rat (Cat. No. UA010786) at 2.0μg/mL (100μL/well) can bind Mouse FGL1 Protein, Fc Tag with EC50 of 0.082-0.107ug/mL.

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