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产品中心 药物靶点和Fc受体 药物靶点

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4-1BB ligand/TNFSF9 Fc Chimera Protein, Mouse

4-1BB Ligand,TNFSF9,CD137L

价格 ￥1,680.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010783
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    4-1BB Ligand, TNFSF9, CD137L

  • Accession

    P41274

  • 表达序列

    Arg104Glu309, with C-terminal Fc

  • 表达宿主

    HEK293

  • 分子量

    60-80kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized 4-1BB/TNFRSF9 His Tag Protein, Mouse (Cat. No. UA010785) at 2.0μg/mL (100μL/well) can bind 4-1BB Ligand/TNFSF9 Fc Chimera, Mouse (Cat. No. UA010783) with EC50 of 3.11-4.30 ng/ mL.

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Cancer Res.2019 Feb 15;79(4):783-794.

背景介绍

  • The 4-1BB ligand (4-1BBL), also known as CD137L, is a type II transmembrane protein that is part of the TNF superfamily. 4-1BBL is the high affinity ligand of 4-1BB. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. 4-1BB Ligand is expressed by activated B cells, monocytes, macrophages, dendritic cells (DC), T cells, lymphoma and multiple myeloma cells, hematopoietic stem cells, early myeloid progenitors, neurons, and astrocytes. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD).

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

    • The purity of 4-1BB Ligand/TNFSF9 Fc Chimera Protein, Mouse is greater than 95% as determined by RP-HPLC.

  • ELISA

    • Immobilized 4-1BB/TNFRSF9 His Tag Protein, Mouse(Cat. No. UA010785) at 2.0μg/mL (100μL/well) can bind 4-1BB Ligand/TNFSF9 Fc Chimera, Mouse(Cat. No. UA010783) with EC50 of 3.11-4.30 ng/ mL.

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