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物种
Human分子别名
Proactivator polypeptide; Saposin-A; PSAP; GLBA; SAP1Accession
P07602表达序列
Ser60-Ser140, with N-terminal His Tag表达宿主
E.coli分子量
10kDa (Reducing)
纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated标签
His Tag性状
Liquid缓冲体系
20 mM HEPES, 150 mM NaCl, pH 7.5
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用
1. 2020 Feb;129(2):161-164. Epub 2019 Aug 5.
2. 2013 Jun 15;22(12):2435-50. Epub 2013 Feb 27
Saposin-A is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D, which are similar to each other and are sphingolipid hydrolase activator proteins. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.
电泳
8μg (R: reducing condition, N: non-reducing condition).
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