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物种
Human分子别名
SLAMF1, SLAM, CD150, SLAMF1, SLAM, CD150Accession
Q13291-1表达序列
Ala21-Lys236, with C-terminal His Tag表达宿主
HEK293分子量
43-55kDa (Reducing)纯度
＞95% by SDS-PAGE & SEC-HPLC内毒素含量
<0.1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized powder缓冲体系
PBS, pH7.4.溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
Castro, A.G. et al. (1999) J. Immunol. 163:5860. Cocks, B.G. et al. (1995) Nature 376:260. Wang, N. et al. (2004) J. Exp. Med. 199:1255. Hahm, B. et al. (2004) Virology 323:292. Nanda, N. et al. (2005) Blood 106:3028. 6.Kiel, M.J. et al. (2005) Cell 121:1109.
The type I transmembrane glycoprotein Signaling Lymphocytic Activation Molecule (SLAM), also known as CD150, is the prototypic member of the SLAM subgroup of the CD2 protein family. Alternate splicing generates an isoform with a substituted cytoplasmic domain. SLAM is expressed on T cells, B cells, thymocytes, macrophages, dendritic cells, platelets, and hematopoietic stem cells. It is up‑regulated on activated B cells and CD4+ and CD8+ T cells, although it is down‑regulated on Th2 polarized cells. SLAM interacts homophilically with low affinity, and this interaction induces a Th0/Th1 response characterized by clonal expansion, production of IFN-gamma, and increased cytolytic activity of CD8+ T cells. SLAM ligation also promotes B cell activation, allergen-induced eosinophil and mast cell activation, NKT cell development, and the microbicidal response of macrophages to Gram negative bacteria. In humans, SLAM functions as a cellular entry receptor for measles virus.
电泳(SDS-PAGE)
1μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
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