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产品中心 药物靶点和Fc受体 药物靶点

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BLAME/SLAMF8 Fc Chimera Protein, Human

BLAME,SLAMF8,CD353

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010769
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    BLAME,SLAMF8,CD353

  • Accession

    Q9P0V8-1

  • 表达序列

    Ala23-Asp233, with C-terminal Fc

  • 表达宿主

    HEK293

  • 分子量

    55-60kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Sci Rep . 2020 Feb 13;10(1):2505.

背景介绍

  • B-lymphocyte activator macrophage expressed (BLAME), also known as SLAMF8, is a type I transmembrane protein that belongs to the CD2 subset of immunoglobulin superfamily cell receptors. BLAME is a cell surface receptor that is expressed upon activation of macrophages (MΦs) by IFN-γ or bacteria, is a negative regulator of ROS in response to Gram+ and Gram- bacteria. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. BLAME is highly expressed in T cells of childhood cancer and Epstein-Barr virus positive gastric cancer, and is a potential immunotherapeutic target for a variety of diseases.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

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