Siglec-7 His Tag Protein, Human

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货号： UA010751

大包装询价

产品介绍引用文献(0) 评论(0)

产品规格

物种

Human
分子别名

CDw328，AIRM-1，Adhesion inhibitory receptor molecule 1，D-siglec，QA79 membrane protein，CD328, siglec-7
Accession

Q9Y286-1
表达序列

Gln19-Leu353, with C-terminal His Tag
表达宿主

HEK293
分子量

45-70kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

His Tag
性状

Lyophilized Powder
缓冲体系

PBS, pH7.4.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1.Crocker, P.R. et al. (1998) Glycobiology 8:v.
2.Crocker, P.R. and A. Varki (2001) Trends Immunol. 22:337.
3.Crocker, P.R. and A. Varki (2001) Immunology 103:137.
4.Angata, T. et al. (2002) J. Biol. Chem. 277:24466.

背景介绍

Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are sialoadhesin/CD169/Siglec-1, CD22/Siglec-2, CD33/Siglec-3, Myelin-Associated Glycoprotein (MAG/Siglec-4a) and Siglecs 5 to 11. To date, no Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells.