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产品中心 药物靶点和Fc受体 药物靶点

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CD2/SRBC Fc Chimera Protein, Cynomolgus

T11,T-Cell Surface Antigen CD2,LFA-2,CD2 Antigens,CD2,LFA-3 Receptor,CD2 Molecule,Rosette Receptor,SRBC,CD2 Antigen,CD2 Antigen (P50),Sheep Red Blood Cell Receptor,T-Cell Surface Antigen T11/Leu-5,Lymphocyte-Function Antigen-2,Erythrocyte Receptor

价格 ￥3,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010735
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Cynomolgus

  • 分子别名

    T11，T-Cell Surface Antigen CD2，LFA-2，CD2 Antigens，CD2，LFA-3 Receptor，CD2 Molecule，Rosette Receptor，SRBC，CD2 Antigen，CD2 Antigen (P50)， Sheep Red Blood Cell Receptor，T-Cell Surface Antigen T11/Leu-5，Lymphocyte-Function Antigen-2，Erythrocyte Receptor

  • Accession

    Q6SZ61

  • 表达序列

    Lys25-Asp209, with C-hIgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    60-65kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Hahn, W.C. et al. (1992). Science. 256:1805. McNerney ME, et al. (2006) The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol. 298: 91-120.

背景介绍

  • T-cell surface antigen CD2 is also known as Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5 and SRBC, is a single-pass type I membrane protein found on the surface of T cells and natural killer (NK) cells. CD2 is a member of the immunoglobulin superfamily.CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function . CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.

  • 生物活性

    • Immobilized CD58/LFA-3 His Tag, Human (Cat. No. UA010759) at 2.0μg/mL (100μL/well) can bind CD2/SRBC Fc Chimera, Cynomolgus (Cat. No. UA010735) with EC50 of 0.14-0.22 μg/mL.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • SPR

    • Anti-His antibody Immobilized on CM5 Chip captured CD58/LFA-3 His Tag, Human (Cat. No. UA010759), can bind CD2/SRBC Fc Chimera, Cynomolgus (Cat. No. UA010735) with an affinity constant of 20.90 nM as determined in SPR assay.

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