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物种
Cynomolgus分子别名
PRR4,LNIR,Nectin cell adhesion molecule 4，PVRL4,Ig superfamily receptor LNIR，Poliovirus receptor-related protein 4,NECTIN4,Poliovirus Receptor-Related 4,Nectin-4,Nectin 4,EDSS1Accession
XP_005541277.1表达序列
Gly32-Ser349, with C-*8His表达宿主
HEK293分子量
40-43kDa (Reducing)纯度
＞95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4.溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1. Reymond, N. et al. (2001) J. Biol. Chem. 276:43205. 2.Takai, Y. et al. (2008) Nat. Rev. Mol. Cell Biol. 9:603. 3.Fabre, S. et al. (2002) J. Biol. Chem. 277:27006.
Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectin extracellular domains (ECDs) contain three Ig-like domains: an N-terminal V-type that mediates ligand binding, and two C2-type .Human Nectin-4 is normally expressed in the placenta, especially in endothelial cells, while in the mouse it is found in the embryo, lung, testis and brain. In humans, mutation of Nectin-4 has been correlated with ectodermal dysplasia-syndactyly syndrome,High Nectin-4/PVRL4 expression was associated with poor-prognosis in some invasive breast cancers and may be a new promising prognostic biomarker and specific therapeutic target.
生物活性
Immobilized Nectin-4 His Tag, Cynomolgus (Cat. No. UA010730)at 2μg/mL (100μL/well) can bind Anti-Human Nectin-4 Monoclonal Antibody with EC50 of 1.52-1.86ng/ml.
电泳
1μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
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