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产品中心 药物靶点和Fc受体 药物靶点

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TNFR-2/CD120b His Tag Protein, Cynomolgus

TNFRSF1B,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR80

价格 ￥3,620.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010721
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Cynomolgus

  • 分子别名

    TNFRSF1B, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR80

  • Accession

    XP_005544817.1

  • 表达序列

    Leu23-Asp257, with C-8*His

  • 表达宿主

    HEK293

  • 分子量

    35-45kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Jingchao Bai , Hui Li. Targeting TNFR2 in Cancer: All Roads Lead to Rome. Front Immunol. 2022 Feb 17:13:844931. eCollection 2022.

背景介绍

  • TNF receptor 2 (TNFR2) has become one of the best potential immune checkpoints that might be targeted, mainly because of its vital role in tumor microenvironments (TMEs). Overexpression of TNFR2 in some tumor cells and essential function in immunosuppressive cells, especially regulatory T cells (Tregs), makes blocking TNFR2 an excellent strategy in cancer treatment; however, there is evidence showing that activating TNFR2 can also inhibit tumor progression in vivo.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • SPR

    • Anti-His antibody Immobilized on CM5 Chip captured TNFR-2/CD120b His Tag, Cynomolgus (Cat. No. UA010721), can bind TNF-α, Human (Cat. No. UA040005) with an affinity constant of 0.46 nM as determined in SPR assay.

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