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产品中心 药物靶点和Fc受体 药物靶点

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Collectrin/TMEM27 Fc Chimera Protein, Human

NX-17 Protein,Human,NX17 Protein

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010719
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    NX-17 Protein, Human; NX17 Protein, Human

  • Accession

    Q9HBJ8

  • 表达序列

    Glu15-Pro141, with C-hIgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    53-60kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Acta Oncol . 2022 Dec;61(12):1507-1511.Epub 2022 Nov 11.

背景介绍

  • Transmembrane protein 27 (TMEM27/collectrin), a glycoprotein and homolog of angiotensin-converting enzyme 2 (ACE2), is a regulator of renal amino acid uptake in the proximal tubule and may have a protective role in hypertension.Mature human Collectrin consists of a 127 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 60 aa cytoplasmic domain. Collectrin is highly expressed in the proximal convoluted tubules of the renal collector and inhibits the proliferation of tubular epithelial cells.Collectrin is also expressed in pancreatic islet beta cells and enhances glucose‑stimulated insulin secretion as well as insulin resistance.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

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