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产品中心 药物靶点和Fc受体 药物靶点

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ERMAP Fc Chimera Protein, Human

hERMAP,MGC118810,MGC118811,PRO2801,RDMGC118812,SC,SCMGC118813

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010717
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    hERMAP; MGC118810; MGC118811; PRO2801; RDMGC118812; SC; SCMGC118813

  • Accession

    Q96PL5

  • 表达序列

    His30-Ala155, with C-hIgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    45-55kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Xu, H. et al. (2001) Genomics 76:2.
    2.Abeler-Dorner, L. et al. (2012) Trends Immunol. 33:34.
    3.Su, M. et al. (2020) Cell. Mol. Immunol.

背景介绍

  • Erythroid membrane-associated protein (ERMAP), also called Scianna blood group antigen, is a member of the butrophilin (BTN) and butrophilin-like (BTNL) family within the immunoglobulin superfamily. ERMAP is an adhesion receptor molecule highly expressed in erythroid tissues, on the cell surface of resting and activated antigen-presenting cells (APCs) and in some tumor tissues. Fusion proteins (ERMAP-Ig) of both human and mouse ERMAP inhibit T cell functions in vitro and administration of the fusion protein ameliorates autoimmune diseases, including experimental autoimmune encephalomyelitis and type 1 diabetes, in mice. ERMAP acts as a novel inhibitory molecule for T cells and macrophages.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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