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产品中心 药物靶点和Fc受体 药物靶点

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TMEM119 Fc Chimera Protein, Human

TMEM119,OBIF

价格 ￥3,620.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010710
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    TMEM119,OBIF

  • Accession

    Q4V9L6

  • 表达序列

    Arg26-Met96, with C-hIgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    37-50kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Jiang, Z,H. et al. (2017) Expt & Mol Med. 49:e329. 2.Satoh, J. et al. (2016) Neuropathol. 36:39.

背景介绍

  • TMEM119 (Transmembrane Protein 119, also known as Osteoblast Induction Factor or OBIF), is an approximately 38-kDa type 1 transmembrane protein. Mature human TMEM119 consists of a 71 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 166 aa cytoplasmic domain. It is predominantly expressed in osteoblasts and is upregulated during osteoblastic differentiation. TMEM-119 is involved in the osteoblast differentiation and bone development by acting as a ligand and has been reported to contribute to the proliferation, migration, and invasion of osteosarcoma cells, as well as functioning as an oncogene in osteosarcoma.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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