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产品中心 药物靶点和Fc受体 药物靶点

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CD24 Fc Chimera Protein, Human

CD24,CD24A

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010702
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CD24,CD24A

  • Accession

    P25063-1

  • 表达序列

    Ser27-Gly59, with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    43-50kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35. 2.Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.

背景介绍

  • Cluster of differentiation 24 is a mucin-type glycosylphosphatidylinositol-linked glycoprotein expressed on the surface of B-cells. High rate of CD24 expressions have been found in epithelial ovarian cancer, breast cancer, non-small cell lung cancer, prostate cancer and pancreatic cancer. It is involved in molecular adhesion and metastatic tumor spread and serve as a normal receptor for P-selectin. The CD24 / P-selectin pathway could be important in disseminating tumor cells by facilitating the interaction with platelet and endothelial cells. It has also been considered as a tumor marker.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

  • ELISA

    • Immobilized CD24 Fc Chimera Protein, Human (Cat. No. UA010702) at 8.0μg/mL (100μL/well) can bind CD24 Recombinant Rabbit mAb (S-974-13) (Cat. No. S0B0725) with EC50 of 1.30-2.94 ng/mL.

  • SPR

    • CM5 Chip captured CD24 Fc Chimera, Human (Cat. No. UA010702), can bind Siglec-10 mFc Chimera, Human (Cat. No. UA010116) with an affinity constant of 2.91 μM as determined in SPR assay.

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