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物种
Human分子别名
ACE-2,ACEHAccession
Q9BYF1-1表达序列
Gln18-Ser740, with C-terminal Human IgG1 Fc&Avi Tag表达宿主
HEK293分子量
120-130kDa纯度
>95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Biotin标签
Human Fc Tag, Avi Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1. RENHONG YAN, YUANYUAN ZHANG, YANING LI, LU XIA, YINGYING GUO, AND QIANG ZHOU: Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2, SCIENCE, 4 Mar 2020, Vol 367, Issue 6485, pp. 1444-1448.
The angiotensin-converting enzyme 2 (ACE2) is the receptor for the three coronaviruses HCoV-NL63, SARS-CoV, and SARS-CoV-2. ACE2 is involved in the regulation of the renin-angiotensin system and blood pressure. ACE2 is also involved in the regulation of several signaling pathways, including integrin signaling. ACE2 expression is regulated transcriptionally and post-transcriptionally. The expression of the gene is regulated by two promoters, with usage varying among tissues. ACE2 expression is greatest in the small intestine, kidney, and heart and detectable in a variety of tissues and cell types. ACE2 receptors are ubiquitous and widely expressed in the heart, vessels, gut, lung (particularly in type 2 pneumocytes and macrophages), kidney, testis and brain. ACE2 is mostly bound to cell membranes and only scarcely present in the circulation in a soluble form. An important salutary function of membrane-bound and soluble ACE2 is the degradation of angiotensin II to angiotensi. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in SARS pathogenesis.
电泳
1μg (R: reducing conditions, N: non-reducing conditions).
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