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产品中心 药物靶点和Fc受体 药物靶点

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EphB4 His Tag Protein, Human

HFASD,LMPHM7,CMAVM2

价格 ￥1,650.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010666
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    HFASD, LMPHM7, CMAVM2

  • Accession

    P54760

  • 表达序列

    Leu16-Ala539, with C-terminal 10*His

  • 表达宿主

    HEK293

  • 分子量

    70-80kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Fuller, T. et al. (2003) J. Cell Sci. 116:2461. 2. Noren, N.K. et al. (2004) Proc. Natl. Acad. Sci. 101:5583. 3. Wang, Z. et al. (2002) Blood 99:2740. 4. Inada, T. et al. (1997) Blood 89:2757.

背景介绍

  • Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 is expressed preferentially on venous endothelial cells (EC) and inhibits cell-cell adhesion, chemotaxis, and angiogenesis. Opposing effects are induced by signaling through Ephrin-B2 expressed on arterial EC: adhesion, endothelial cell migration, and vessel sprouting. EphB4 singaling contributes to new vascularization by guiding venous EC away from Ephrin-B2 expressing EC. Ephrin-B2 signaling induces arterial EC to migrate towards nascent EphB4 expressing vessels. The combination of forward signaling through EphB4 and reverse signaling through Ephrin-B2 promotes in vivo mammary tumor growth and tumor-associated angiogenesis. EphB4 promotes the differentiation of megakaryocytic and erythroid progenitors but not granulocytic or monocytic progenitors.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized Ephrin-B2 Fc Chimera Protein, Human (Cat. No. UA010160) at 2.0μg/mL (100μL/well) can bind EphB4 His Tag Protein, Human (Cat. No. UA010666) with EC50 of 0.15-0.27μg/mL .

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