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产品中心 药物靶点和Fc受体 药物靶点

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LDLR(D193A) His Tag Protein, Human

FH,FHC,LDL R,LDL Receptor,LDLCQ2

价格 ￥4,230.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010661
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    FH, FHC, LDL R, LDL Receptor, LDLCQ2

  • Accession

    P01130

  • 表达序列

    Ala22-Arg788(Asp193Ala), with C-terminal 8*His

  • 表达宿主

    HEK293

  • 分子量

    110-120kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1． Nature Cell Biology volume 25, pages937-949 (2023)Cite this article.

背景介绍

  • Low density lipoprotein (LDL) receptor also known as LDLR, FH, FHC, LDLCQ2 is a Mosaic protein that belongs to the low density lipoprotein receptor gene family. LDL receptors are translated by ribosomes on the endoplasmic reticulum and are modified by the Golgi apparatus before travelling in vesicles to the cell surface. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

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