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产品中心 药物靶点和Fc受体 药物靶点

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IGFBP-3 His Tag Protein, Human

IGFBP3,IBP3,IBP-3,IGF-binding protein 3,IGFBP-3

价格 ￥3,020.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010654
规格
数量
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产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    IGFBP3, IBP3, IBP-3, IGF-binding protein 3, IGFBP-3

  • Accession

    P17936-1

  • 表达序列

    Gly28-Lys291, with C-terminal 10*His

  • 表达宿主

    HEK293

  • 分子量

    47-54kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Ling (1991) Prog. Growth Factor Res. 3:243. 2. Baxter, R.C. (2013) J. Cell Commun. Signal 7:179.

背景介绍

  • Insulin-like growth factor binding protein-3 (IGFBP-3) is a member of the IGFBP family. Human IGFBP-3 is comprised of 264 amino acids, of which the molecular mass is 28.7 kDa without any post-translational modifications. The primary structures of human IGFBP-3 consist of three distinct domains: a highly conserved cysteine-rich N- and C-terminal domains and a nonconserved central domain. Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated protein and a major carrier for IGFs in circulation. Disruption of IGFBP-3 at transcriptional and post-translational levels has been implicated in the pathophysiology of many different types of cancer including breast, prostate, and lung cancer. The principal action of IGFBP-3 is to transport IGF-I and IGF-II in circulation, and, thereby, prolong the half-life of IGFs. IGFBP-3 can inhibit or enhance IGF actions, depending on cell types, the cellular environment, IGFBP-3 concentration, and post-translational modifications such as glycosylation, proteolysis, and phosphorylation. Moreover, IGFBP-3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • SPR

    • Anti-His antibody Immobilized on CM5 Chip captured IGFBP-3 His Tag, Human (Cat. No. UA010654), can bind IGF-I, Human (Cat. No. UA040055) with an affinity constant of 9.01 nM as determined in SPR assay.

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