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产品中心 药物靶点和Fc受体 药物靶点

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GLP-1R Fc Chimera Protein, Human

GLP-1 receptor,GLP1R,GLP-1R,GLP-1-R,glucagon-like peptide 1 receptor,MGC138331

价格 ￥2,800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010634
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    GLP-1 receptor, GLP1R, GLP-1R, GLP-1-R, glucagon-like peptide 1 receptor, MGC138331

  • Accession

    P43220-1

  • 表达序列

    Ala21-Glu139, with C-terminal Human IgG Fc

  • 表达宿主

    HEK293

  • 分子量

    50-60kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

背景介绍

  • Glucagon-like peptide-1 receptor (GLP-1R) is a class B G-protein-coupled receptor. Human GLP-1R consists of an N-terminal, extracellular domain (ECD) containing 6 conserved cysteine residues and a transmembrane domain with seven membrane-spanning alpha-helices, characteristic of GPCRs. Activation of GLP-1R signaling regulates secretion of insulin from pancreatic beta -cells in a glucose-dependent manner. Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic properties in animal models and to impact glucose-dependent insulin release, satiety, memory, and learning in man.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized GLP-1R Fc Chimera Protein, Human (Cat. No.UA010634) at 1.0μg/mL (100μL/well) can bind Anti-Gulgafafusp alfa Monoclonal Antibody (Glutazumab) (Cat. No. UA016034) with EC50 of 3.80-6.34 ng/mL.

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