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产品中心 药物靶点和Fc受体 药物靶点

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LILRA2 Fc Chimera Protein, Human

ILT1,LIR7,CD85H,LIR-7,LILRA2,ILT1CD85H,CD85h,ILT-1,CD85h antigen,CD85 antigen-like family member H

价格 ￥3,600.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010625
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    ILT1,LIR7,CD85H,LIR-7,LILRA2,ILT1CD85H,CD85h,ILT1,ILT-1,ILT1CD85H,CD85h antigen,CD85 antigen-like family member H

  • Accession

    Q8N149-1

  • 表达序列

    Gly24-Asn449, with C-terminal Human IgG Fc

  • 表达宿主

    HEK293

  • 分子量

    90-100kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Gene ID: 11027, updated on 18-Aug-2023.

背景介绍

  • LILRA2(leukocyte immunoglobulin like receptor A2), also known as CD85H and LIR7(Leukocyte immunoglobulin like receptor 7), belongs to the Class A subfamily of LIR receptors (LILRAs) and is a single-generation type I transmembrane protein. Mature human LILRA2 consists of a 426 amino acid (aa) extracellular domain (ECD) with 4 Ig-like domains, a 21 aa transmembrane segment, and a 13 aa cytoplasmic tail. LILRA2 is expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. LILRA2 cross-linking on monocytes induces pro-inflammatory cytokines while inhibiting dendritic cell differentiation and antigen presentation.

  • 电泳

    • 2μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized LILRA2 Fc Chimera Protein, Human (Cat. No. UA010625) at 2.0μg/mL (100μL/well) can bind LILRA2 Recombinant Rabbit mAb (S-287-234) (Cat. No. S0B0643) with EC50 of 7.83-10.33ng/mL.

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