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产品中心 药物靶点和Fc受体 药物靶点

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Biotinylated Her3 His&Avi Tag Protein, Human

Her3,FERLK,LCCS2,VSCN1

价格 ￥2,340.00 （ 1-2周）
货号 UA010622
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Her3,FERLK,LCCS2,VSCN1

  • Accession

    P21860

  • 表达序列

    Ser20-Thr643, with C-terminal 10*His &Avi tag

  • 表达宿主

    HEK293

  • 分子量

    90-95kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Biotin

  • 标签

    Avi Tag, His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Zhang N. et al. (2016) HER3/ErbB3, an emerging cancer therapeutic target. Acta Biochim Biophys Sin. 48(1): 39-48.

背景介绍

  • HER3 is a member of the HER (EGFR/ErbB) receptor family consisting of four closely related type 1 transmembrane receptors (EGFR, HER2, HER3, and HER4). HER receptors are part of a complex signaling network intertwined with the Ras/Raf/MAPK, PI3K/AKT, JAK/STAT, and PKC signaling pathways. Aberrant activation of the HER receptors and downstream signaling molecules tips the balance on cellular events, leading to various types of cancers. The HER3 protein is expressed in several types of tumors. That fact, together with the role of HER3 in promoting cell proliferation, implicate that targeting HER3 may have therapeutic relevance. Furthermore, expression and activation of HER3 has been linked to resistance to drugs that target other HER receptors such as agents that act on EGFR or HER2.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized Biotinylated Her3 His&Avi Tag, Human (Cat. No. UA010622) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind Anti-Human HER3 Monoclonal Antibody (Patritumab) with EC50 of 2.13-2.31 ng/ml.

    • Immobilized Biotinylated Her3 His&Avi Tag Protein, Human (Cat. No.UA010622) at 2.0μg/mL (100μL/well) can bind Human NRG1 Beta 1 Protein, Fc Tag, premium grade with EC50 of 0.76-1.94 ng/mL.

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