分享产品介绍 评论(0)
物种
Human分子别名
CD85 antigen-like family member G,Immunoglobulin-like transcript 7,ILT7Accession
P59901-1表达序列
Glu24-Asn446, with C-terminal 8*His表达宿主
HEK293分子量
64-73kDa
纯度
>95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.Wei Cao, Laura Bover. Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev. 2010 Mar;234(1):163-76.
LILRA4 (also known as ILT7 and CD85g) encodes a preprotein of 499 amino acids that gives rise to a surface receptor with four extracellular immunoglobulin domains, a transmembrane domain, and a short intracellular tail. The human LILR family of immunoreceptors is found on NK cells, T cells, monocytes, B cells, and dendritic cells. LILRA4 is a negative regulatory receptor that is found on resting pDCs and strongly downregulated after viral or bacterial stimulation. LILRA4 protein directly binds to and can be activated by bone marrow stromal cell antigen 2 (BST2; CD317) protein, the expression of which is found on cells preexposed to IFN or on the surface of human cancer cells. The interaction between ILT7 and BST2 functions to assure an appropriate TLR response by pDCs during viral infection and likely participates in pDC-tumor crosstalk.
电泳
1μg (R: reducing conditions, N: non-reducing conditions).
ELISA
Immobilized Anti-Human LILRA4 Monoclonal Antibody(Daxbio) at 2.0μg/mL (100μL/well) can bind LILRA4 His Tag, Human (Cat. No. UA010616) with EC50 of 0.16-0.22 μg/mL.
评论(0)