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产品中心 药物靶点和Fc受体 药物靶点

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FKBP12 His Tag Protein, Human

FKBP-12,FKBP-1A,FKBP1,FKBP12,PKC12,PKCI2,PPIASE

价格 ￥1,250.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010605
规格
数量
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产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    FKBP-12,FKBP-1A,FKBP1,FKBP12,PKC12,PKCI2,PPIASE

  • Accession

    P62942

  • 表达序列

    Met1-Glu108, with C terminal 8*His Tag MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLEHHHHHHHH

  • 表达宿主

    E.coli

  • 分子量

    13kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Curr Genet. 2021 Jun;67(3):383-388.
    2. Genetics. 1999 Mar;151(3):935-44.

背景介绍

  • FKBP12 associates with several large protein complexes, including the multi-drug resistance pump and the ryanodine, inositol trisphosphate (IP3)and the type I TGF-β receptor. FKBP12 was originally identifed as a FK506 binding protein. FK506 is a clinically used immunosuppressant derived from Streptomyces tsukubaensis. The FK506–FKBP12 binary complex inhibits the protein phosphatase calcineurin, thereby preventing T lymphocytes from producing interleukin-2 in mammals.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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