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产品中心 药物靶点和Fc受体 药物靶点

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CD3 gamma Fc Chimera Protein, Human

T-cell receptor T3 gamma chain,T-cell surface glycoprotein CD3 gamma chain

价格 ￥2,784.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010598
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    CD3 gamma

  • 分子别名

    T-cell receptor T3 gamma chain, T-cell surface glycoprotein CD3 gamma chain

  • Accession

    P09693

  • 表达序列

    Gln23-Ser116, with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    43-50kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Michael S Kuhns, Mark M Davis, K Christopher Garcia. Deconstructing the form and function of the TCR/CD3 complex. Immunity. 2006 Feb;24(2):133-9.

背景介绍

  • T-cell surface glycoprotein CD3 gamma chain, also known as CD3G, is a 20 kDa single-pass type I membrane protein that is part of the TCR-CD3 complex. CD3 gamma is located on human chromosome 11 and mouse chromosome 9. CD3 gamma, a subunit of the T cell receptor-CD3 (TCR/CD3) complex, helps to support surface TCR/CD3 expression and participates in signal transduction for gene induction after antigen recognition by T lymphocytes, and in TCR/CD3 down-modulation. The TCR/CD3 complex is assembled after a series of pairwise interactions involving the formation of dimers of CD3 epsilon with either CD3 gamma or CD3 delta. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Measured by its binding ability in a functional ELISA. When Recombinant Human CD3 gamma Fc Chimera (Cat. No.UA010598) is immobilized at 1.0 μg/mL, the concentration of Biotinylated Recombinant Human CD3E Fc Chimera(Cat. No. UA010199) that produces 50% of the optimal binding response is approximately 2.2-3.2 μg/mL.

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