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产品中心 药物靶点和Fc受体 药物靶点

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TMEM219 Fc Chimera Protein, Human

IGFBP-3R,Transmembrane protein 219,TMEM219

价格 ￥5,360.00 （ 1-2周）
货号 UA010594
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 抗原名称

    TMEM219

  • 分子别名

    IGFBP-3R, Transmembrane protein 219, TMEM219

  • Accession

    Q86XT9-1

  • 表达序列

    Ser39-Arg204, with C-terminal Human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    60-65kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Chang-Min Lee , Chuan Hua He.IL-13Rα2 uses TMEM219 in chitinase 3-like-1- induced signalling and effector responses.Nat Commun. 2016 Sep 15;7:12752.

背景介绍

  • TMEM219 is a recently discovered death receptor, which induces cell apoptosis by a Caspase-8-dependent mechanism, through the binding with its ligand, the Insulin-like growth factors binding protein 3 (IGFBP3). TMEM219 consists of four exons comprising the 915-base pair cDNA sequence on chromosome 16q13 and represents a 240-amino acid polypeptide. TMEM219 is expressed on pancreatic beta cells and that signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) leads to beta cell loss and dysfunction. TMEM219 is an IL-13Rα2 binding partner that plays a critical role in many Chi3l1-induced, IL-13Rα2-mediated cellular and organ responses.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

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